Wie zijn we ?
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Ben Van Camp
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Karin Vanderkerken
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Rik Schots
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Fabienne Trullemans
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Ann De Becker
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Charlotte Caron
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Karel Fostier
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Ivan Van Riet
- Nicole Arras
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Angelo Willems
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Eline Menu
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Elke De Bruyne
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Carine Seynaeve
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Dehui Xu
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Jinsong Hu
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Miguel Lemaire
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Sarah Deleu
- Song Xu
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Marleen Bakkus
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Els van Valckenborg
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Rik De Raeve
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Ann Blank
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Dorien Deneve
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Anne Willekens
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Gerrit Ponet
Contact information: ben.vancamp@uzbrussel.be
UZ Brussel
Division of Clinical Hematology
Laarbeeklaan 101
B-1090 Brussel
Belgium
Tel: 00 32 2 477 62 11
Fax: 00 32 2 477 62 10
Education:
Doctor in Medicine, Vrije Universiteit Brussel( 1971)
PhD in Medical Sciences, Vrije Universiteit Brussel (1980)
Specialist in Internal Medicine ( 1976)
Special competence in Hematology ( recent legal title )
Scientific positions:
Visiting doctoral Fellow TNO, Rijwijk, Nl (1974)
Visiting Postdoctoral Fellow Stanford Medical School, CA, USA (198O)
Visiting Professor Cancer Centre Tucson University, Arizona, USA (1988)
Belgian Franqui Chair, UA ( 2002)
Actual functions:
Full professor in Hematology
Head of department of Medical Oncology and Hematology, UZBrussel Hospital of the Vrije Universiteit Brussel) (since 1985)
Chairman of Strategic committee of UZBrussel
Member of the Royal Academy of Medicine, Belgium
Chairman and member of national and international scientific advisory boards ( field of Hematology, Clinical Inmmunology, Cancer, and more spec. Multiple Myeloma )
Head of the researchgroup Hematology and Immunology, faculty of Medecine, Vrije Universiteit Brussel ( VUB )
Former positions:
Dean of the faculty of Medecine ( 1994-2000 )
Rector of the Vrije Universiteit Brussel (2000-2008)
Publications:
See website.
Contact information: Karin.Vanderkerken@vub.ac.be,
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D033
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 18
tel: 00 32 2 477 44 06 (secr)
fax: 00 32 2477 44 05
Education:
Master in Biology (Zoology) (VUB, 1987)
Aggregation HSO (VUB, 1988)
PhD in Sciences (VUB, 1994)
Actual functions:
Associate professor (100%, hoofddocent)
Vice-Chair educational committee Master Biomedical Sciences
Vice-Chair research council of the Faculty of Medicine and Farmacy
Member of the Faculty Council
Member of the Research Council VUB
Member of the Ethical Committee of Animal Experimentation
Member of the Committee of Biosafety
Member of the Ledencommissie FWO
Scientific Member of the Vlaamse Kankerliga
Teaching courses:
Coordinator “Experimentele Cellulaire en Moleculaire Biologie” part I, II and III in second and third year bachelor Biomedical Sciences VUB
“teacher” “Experimentele Cellulaire en Moleculaire Biologie” part I
Coordinator traineeships in first master Biomedical Sciences VUB
Coordinator traineeship in first master Biomedical Sciences VUB
Publications:
see website
Memberships of professional organizations:
Begian Hematology Society
American Society of Hematology
Belgische Vereniging voor de Studie van Kanker
Name: SCHOTS Rik (Tienen 1958)
Contact information: Rik.Schots@uzbrussel.be
UZ Brussel
Division of Clinical Hematology
Laarbeeklaan 101
B-1090 Brussel
Belgium
Tel: 00 32 2 477 62 11
Fax: 00 32 2 477 62 10
Education:
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Doctor in Medicine, Vrije Universiteit Brussel (1983)
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Specialist Internal Medicine (1989)
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Master Medical and Pharmaceutical Research (1989)
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PhD in Medical Sciences, Vrije Universiteit Brussel (2003)
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Special competence in Clinical Hematology (2003)
Current positions:
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Head of Division of Clinical Hematology, Universitair Ziekenhuis Brussel (UZB)
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Director Hematopoietic Stem cell Transplantation Programme UZB
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Medical director of the “Hematopoietische stamcel bank UZB”
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Associate Professor (10%) Faculty of Medicine Vrije Universiteit Brussel (VUB)
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President Transfusion Committee UZB
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Coördinator of the Myeloma Study Group of the Belgian Hematological Society
Research projects
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Principal investigator and co-investigator in several phase II and III clinical trials (lymphoma, myeloma, leukemia)
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Study of inflammatory parameters after allogeneic hematopoietic stem cell transplantation and and their value to predict severe transplant-related complications
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Study on the role of CD34+ stem cell selection and fixed T cell add-back after allogeneic hematopoietic stem cell transplantation
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Participation in research projects related to multiple myeloma and stem cell research
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A clinical protocol for unrelated umbilical cord blood transplantation after myeloablative or nonmyeloablative conditioning in adult patients with hematological diseases. A joint UZ Brussel – UZ Gent project, supported by the BHS transplant subcommittee
Memberships of professional organizations:
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American Society of Hematology (ASH)
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Belgian Hematological society (BHS)
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European Hematological Association (EHA)
Publications:
Use link to “HEIM”
Name: VAN RIET Ivan
Contact information: Ivan.vanriet@uzbrussel.be
UZ Brussel
Division of Clinical Hematology
Laarbeeklaan 101
B-1090 Brussels
Belgium
Tel: 00 32 2 477 62 11
Fax: 00 32 2 477 67 28
Education:
Master in Biological Sciences (1983 – VUB)
Master in Medical and Pharmaceutical Research (1986 – VUB)
PhD in Biomedical Sciences (1994 – VUB) PhD thesis: “Homing of myeloma cells and its implication for autologous stem cell transplantation”
Actual functions:
Director Stem Cell Laboratory – Clinical Hematology UZ Brussel
Associate professor (10% ZAP) faculty of medicine VUB
JACIE stem cell laboratory inspector
Board member HOVON working group Stem Cell Laboratories (WSN)
Research projects/interests:
Tumor–microenvironment interactions in Multiple Myeloma
Biology and clinical use of blood and bone marrow stem cells
Processing and banking of hematopoietic stem cells for clinical use
Teaching courses:
Master in Biomedical Sciences for Cell and Gene Therapy VUB
First year: Class: “Molecular targets in cancer” Course: “Molecular targets in hematological malignancies”
Second year: Class: “Hematopoietic cell therapies” (coordinator). Course: “Biology and in vitro processing of hematopoietic stem cells”
Publications:
See website
Memberships of professional organizations
International Society of cellular Therapy (ISCT)
European Blood and Marrow Transplantation Group (EBMT)
Belgian Hematological Society (BHS)
Belgian Society for Tissue Banking (BVWB)
Name: ARRAS Nicole
Contact information: narras@vub.ac.be
Vrije Universiteit Brussel (VUB)
BTC Building, first floor
UZ Brussel
Stem Cell Laboratory
Laarbeeklaan 105
B-1090 Brussels
Belgium
Tel: 00 32 2 477 67 02
Fax: 00 32 2 477 67 28
Education:
Bachelor in Biomedical Laboratory Technology - Medical Laboratory Technology 1970
Actual function:
Senior laboratory technician
Membership of professional organization:
Secretary of Belgische Vereniging van Laboratorium Technologen
Name: Willems Angelo
Contact information: awillems@vub.ac.be
Vrije Universiteit Brussel (VUB)
Building D, Level 0, Room D002
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel : 00 32 2 477 44 02
fax : 00 32 2 477 44 05
Education:
Bachelor in Biomedical Laboratory Technology - Farmaceutical and Biological Laboratory Techniques
Actual functions:
Laboratory technician
Membership of professional organizations:
Belgian Hematological Society
Name: MENU Eline
Contact information: emenu@vub.ac.be
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D003
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 01
fax: 00 32 2477 44 05
Education
Master in Biomedical Sciences, 2001, VUB
Doctor in Medical Sciences, 2006, VUB
Actual function:
Post-doctoral fellow
Research project:
Myeloma cells reside in the bone marrow (BM) where they interact with the stroma compartment to receive survival signals. The project consists of investigating these interactions and to study the proliferative and anti-apoptotic effect of BM stroma, both through adhesion molecules and cytokines. Effects on cell cycle progression of the MM cells and their sensitivity to cytotoxic drugs are analyzed. The therapeutic use of cytokine and/or integrin inhibitors are also investigated.
Name: DE BRUYNE Elke
Contact information: eldebruy@vub.ac.be
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D003
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 01
fax: 00 32 2477 44 05
Education:
Master in Biomedical Research, 2003, VUB
FELASA C
Actual function:
PhD student and teaching assistant (courses Experimental cellular and molecular biology I-III)
Research project
In multiple myeloma (MM), cancer cells receive signals to survive and proliferate due to the existence of functional, mutual interactions between the MM cells and the stromal BM cells. The aim of the project is to determine to what extent the endothelial cells and IGF-1 contribute to the BM microenvironmental induced modulation of gene-expression of MM cells by using Affymetrix cDNA microarrays (MOE430A). We mainly focus on genes involved in migration, adhesion, invasion, homing, proliferation, protection against cell death and radioresistence.
Publications: see website
Name: SEYNAEVE Carine
Contact information: cseynae@vub.ac.be
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D014
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 17
fax: 00 32 2477 44 05
Education:
Bachelor in Chemistry
Function:
Laboratory Technician
Name: XU dehui
Contact information: dehuixu@hotmail.com
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D038
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 06
fax: 00 32 2477 44 05
Education:
Clincal medicine, xi'an jiaotong university, 2005
Genetics, xi'an jiaotong university, 2008
Actual function:
PhD student
Research project:
The main research focuses on the interactions of the myeloma cells with the bone marrow microenvironment and how these interactions mutually influence both the myeloma cells and the microenvironment, with particular interest in the tumor cell survival and proliferation, and the myeloma induced bone disease (activation of osteoclasts and inhibition of osteoblasts) and angiogenesis (activation of endothelial cells).
Name: HU Jinsong
Contact information: Jinsong.Hu@vub.ac.be
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D004
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 02
fax: 00 32 2477 44 05
Education:
Bachelor of Science in Biology, Shaanxi Normal University (P.R. China) 1996
Master of Medicine, Xi'an Jiaotong University (P.R. China) 2003
PhD, Fourth Military Medical University (P.R. China) 2008
Actual function:
PhD student
Research Projects:
The roles of Notch signaling in 5T33MM.
Notch signaling regulates VEGF responsiveness.
The crosstalk between Notch and hypoxia.
Hypoxia-activated treatment for multiple myeloma in 5T33MM model
Membership of professional organization:
CSCB (Chinese Society for Cell Biology)
Name: LEMAIRE Miguel
Contact information:
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D0
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 04
fax: 00 32 2477 44 05
Education:
Master in Biomedical Sciences
Function:
PhD student
Research Projects:
We study the combined effect of histone deacetylase inhibitor LBH589 and IGF-1 Receptor inihibitor PPP on the 5T33MM murine model. Our aim is to find out if there is any in vitro effect on cell proliferation, cell-cyclus and or apoptosis. With the in vivo experiments we would like to test te clinical relevance of this combined therapy and its effects on tumor burden, bone disease, angiogenesis and survival.
Further, we will try to identify some of the downstream targets and gene expression profiles of 5TMM cells treated with either compound alone or in combination (GOA project).
In parallel, we are trying to improve the visualisation of 5TMM cells making use of luciferase protein or nanobodies (in cooperation with Prof. S. Muyldermans).
Name: DELEU Sarah
Contact information: sidele@vub.ac.be
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D004
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 01
fax: 00 32 2477 44 05
Education
Master in Biomedical Siences
Actual function:
PhD Student
Research project:
The influence of histone deacetylase inhibitors in the pathogenesis of multiple myeloma, using the 5T2MM and 5T33MM murine myeloma models that mimick the MM disease closely, both on a molecular, cellular and clinical level.
Name: VAN VALCKENBORGH ElS
Contact information: els.van.valckenborgh@vub.ac.be
Vrije Universiteit Brussel (VUB)
Building D, level 0, Room D006
Faculty of Medicine and Farmacy
Department of Hematology and Immunology
Laarbeeklaan 103
B-1090 Brussels
Belgium
tel: 00 32 2 477 44 04
fax: 00 32 2477 44 05
Education
Master in Biomedical Sciences, 2000, VUB
Doctor in Medical Sciences, 2005, VUB
Actual function:
Post-doctoral fellow
Research project:
Current cancer therapy is mostly based on the model that all cancer cells in a tumour can proliferate extensively and can form new tumours. The cancer stem cell model suggests that only a small subpopulation of the cancer cells can proliferate and drives the formation and growth of tumours. This research project is focused on the identification and characterisation of the multiple myeloma stem cell in the 5TMM murine models. This project is part of a translational programme in an European network (EU FP6), MSCNET (Myeloma Stem Cell Network).