Gehonoreerde projecten wetenschappelijk Fonds Willy Gepts

2018

  • Accelerated deep TMS in the elderly depressed: a brain imaging approach - Baeken Chris
  • Self-perceived fatigue in childhood cancer survivors, in relation to body composition, physical outcomes and inflammatory parameters - Ceulemans Anne
  • Initiation of ovarian stimulation with recombinant-human FSH (Bemfola®) in the late follicular phase, a randomised controlled pilot study - De Rijdt Sylvie
  • mRNA therapy for experimental beta(-like) cell transplantation - De Leu Nico
  • A population-level evaluation of the quality of end-of-life care - De Schreye Robrecht
  • DIabetes Mellitus patients undergoing SUrgery on foot Ulcers: what is their Metabolic profile and are nutritional goals met? - De Waele Elisabeth
  • Augmented Reality 3D representation of ultrasound medical images for use in interventional procedures - Duerinck Johnny
  • Exploring coagulation activation during hemodialysis and clinical validation of a hemodialysis strategy free of systemic anticoagulation - Francois Karlien
  • The development and evaluation of an advance care planning programme in nursing homes in Flanders: a cluster randomised controlled trial and mixed-methods process evaluation - Gilissen Joni
  • USP13 mediated inhibition of cCBL, a novel co-target for EGFR targeted therapies in EGFR mutant non-small cell lung cancer - Giron Philippe
  • Turn back the TIMe of the lung Tumor /nfiltrating Myeloid cells - Goyvaerts Cleo
  • De-resuscitation phase after fluid resuscitation (DARE) during septic shock in patients not transgressing spontaneously to flow phase: Removal of extravascular fluid with continuous renal replacement therapy using hypertonic solutions: Fact or Fiction? - Jacobs Rita
  • Establishment of a 3D-skin culture model to study the therapeutic effect of an herbal formulation on atopic dermatitis-like or psoriasis-like features - Kortekaas Inge
  • Translational CD20 nanobody theranosis: diagnostic imaging and targeted radionuclide therapy of Non-Hodgkin Lymphoma with anti-CD20 nanobody in a humanized mouse model - Krasniqi Ahmet
  • Reducing sleep onset latency with virtual reality in patients suffering from diabetic polyneuropathy. RESOLVE - Moens Maarten
  • Treatment of PREPL deficiency with trimethoprim - Regal Luc
  • The influence of different thyroid autoantibodies on thyroid function and pregnancy outcome after assisted reproductive technology - Unuane David
  • Impact of non-HLA susceptibility alleles on the various asymptomatic stages of type 1 diabetes - Van de Casteele Marc
  • ChIP-NIPT: a novel approach to enrich the foetal fraction in non-invasive prenatal testing to reliably detect (sub)chromosomal copy number variations Van Dooren Sonia
  • Influence of Assisted Autogenic Drainage and Assisted Autogenic Drainage combined with bouncing on gastro-oesophageal reflux in infants under the age of one year. Van Ginderdeuren Filip

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2017

  • Human in-vitro spermatogenesis through tissue engineering: tracking differentiation in 3D bioprinted testicular constructs - Baert Yoni
  • Changes in the inflammatory gene expression in older adults after 3 months of physical exercise: The Senior PRoject INtensive Training (SPRINT) study - Bautmans Ivan
  • Are ICSI men and women at risk for infertility and/or cardiometabolic morbidity? - Belva Florence
  • FIX-DMD": Development of Next-Generation Gene Therapy for Duchenne Muscular Dystrophy by Heart- and Skeletal Muscle-Specific Targeting - Chai, Yoke Chin
  • Modulation of neuronal fear circuits through transcranial direct current stimulation (tDCS) - De Bundel Dimitri
  • What is the origin of epigenetic changes after assisted reproductive technologies? - De Rycke Martine
  • Nanobody based targeted radionuclide therapy amplified with Cherenkov luminescence activated photodynamic therapy - Debie Pieterjan
  • Impact of daratumumab on the immune environment in multiple myeloma patients - Fostier Karel
  • Optimisation of induced pluripotent stem cell reprogramming using oocyte-specific factors - Geens Mieke
  • Mechanisms of autoallergy and disease chronicity in endophenotyping of atopic dermatitis - Gutermuth Jan
  • Definition of reference markers for therapeutic potential of human beta cells in preclinical transplantation - Jacobs-Tulleneers-Thevissen Daniel
  • Screening of auto-reactive antibodies in neonates to predict the development of allergic- and inflammatory diseases in a prospective UZ Brussel birth-cohort (the All in UZ study) - Janmohamed Sherief
  • Exploring the therapeutic potential of targeting mitotic exit in combination with standard of care agents for high grade B cell malignancies - Maes Anke
  • Development of a human skin stem cell-derived in vitro model to study non-alcoholic steatohepatitis - Marcelino Rodrigues Robim
  • System xc– as a novel therapeutic target to limit neurodegeneration in Parkinson’s disease - Massie Ann
  • Development of in vitro and in vivo strategies to avoid and cure male infertility: Optimisation of immature testicular tissue grafting - Ntemou Ellissavet
  • Development of in vitro and in vivo strategies to avoid and cure male infertility: Optimization and clinical safety of freezing protocol - Onofre Meza Jaime
  • Joint Reconstruction of Activity and Attenuation in Time-of-Flight Positron Emission Tomography - Salvo Koen
  • Molecular analysis of aberrant AZFb deletion patterns - Stouffs Katrien
  • Maternal weight loss and endothelial function in her offspring: difference between prepregnancy weight loss after bariatric surgery versus intrapregnancy lifestyle intervention weight loss in obese mothers - Van De Maele Karolien
  • School reintegration of childhood brain tumour survivors: development of policy recommendations - Vanclooster Stefanie

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2016

  • Mutations in HRD genes as predictive biomarkers for the effectiveness of neoadjuvant carboplatinum in the and postoperative irradiation in triple negative early breast cancer patients - Fontaine Christel
  • Use of high throughput whole-genome sequencing (WGS) in the typing and epidemiologic surveillance of Bordetella pertussis - Pierard Denis
  • The search for the origin of chromosomal abnormalities in human preimplantation embryos - Sermon Karen
  • Study of mitochondrial DNA changes in placental samples of spontaneous and IVF conceptions - Spits Claudia
  • Immune checkpoint modulation in multiple myeloma: can iNKT cells be targeted? - Favreau Mérédis
  • Intravital imaging of tumor targeting with nanobodies - Hernot Sophie
  • Evaluation of 68Ga-NOTA-Anti-HER2 Nanobody uptake in brain metastasis of breast carcinoma patients using PET/CT scan - Keyaerts Marleen
  • A preclinical study to investigate the potential of S100A9 inhibitors in the treatment of Multiple Myeloma - Vanderkerken Karin
  • Development of a GMP compliant and fully automated 18F-radiochemistry unit for clinical translation of 18F-nanobodies - Vaneycken Ilse
  • Hair Cortisol Concentration as a Biomarker for Parental Stress. A study of the correlation between the chronic cortisol response in parents and pathology in their children, and its possible mediation by attachment status of the child - Campforts Edward
  • N-acetylcysteine for the treatment of cannabis dependence: working mechanisms - Crunelle Cleo
  • OptiBIRTH: Improving the organisation of maternal health service delivery, and optimising childbirth, by increasing vaginal birth after caesarean section (VBAC) through enhanced women-centred care – health economic analysis - Fobelets Maaike
  • Phase I clinical trial on systemic PD-1 blockade in combination with intra-tumoral CTLA-4 immune-checkpoint blockade following the resection of recurrent glioblastoma - Neyns Bart
  • The systematic early integration of palliative care into multidisciplinary oncology care in the hospital setting (IPAC), a randomized controlled trial - Vanbutsele Gaelle
  • The impact of maternal decidualization on human blastocyst development - Aberkane Asma
  • Significance of cytokines as markers for oocyte quality, embryo development and clinical pregnancy in ART patients - Anckaert Ellen
  • Oxygen a key regulator for implantation and trophoblast differentiation - Vandevelde Hilde
  • CAMEL-KIT: Single-step labeling of single domain antibody fragments with 68Ga for PET imaging - Baudhuin Henri
  • Translational CD20 nanobody theranosis: diagnostic imaging and targeted radionuclide therapy of Non-Hodgkin Lymphoma with anti-CD20 nanobodies in a humanised mouse model - Devoogdt Nick
  • Targeting brain tumors and metastases using therapeutic radiolabeled Nanobodies - D'Huyvetter Matthias
  • On-line CAre for secondary stroke Prevention (OCAPi) - Brouns Raf
  • Using a Humanoid Robot to Provide Pain Neuroscience Education to Children with Leukemia Undergoing Painful Procedures: a Monocentric Pilot Study - Ickmans Kelly
  • Development and evaluation of a computerized clinical decision support system for drug allergy checking - Legat Laura
  • Complexity and multidisciplinary approach to fetal pathology: can we improve diagnostics and enhance geno-/phenotype correlation? - Van Berkel Kim
  • Reprogramming of umbilical cord-derived mesenchymal stem cells towards hepatocyte-like cells by repeated expression of hepatic transcription factors - Buyl Karolien
  • Biomarker discovery and advanced monitoring of new cell-based therapies for hereditary tyrosinemia type 1 - De Kock Joery
  • Hemichannels as novel pharmacological targets and biomarkers of cholestasis - Vinken Mathieu
  • Klinefelter related infertility: getting to know causes - Van Saen Dorien
  • The effect of meiotic gene mutations on human reproduction - Verpoest Willem
  • Role of natural killer cells in HIV post-treatment control - Aerts Joeri

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2015

  • The development of a 3D culture system for human in-vitro spermatogenesis - Baert Yoni
  • Minimal residual disease quantification using high-throughput IGH sequencing in multiple myeloma patients who received dendritic cell based immunotherapy - Bakkus Marleen
  • PET-imaging of tumour supporting macrophages in the tumour microenvironment using 18FNanobodies - Blykers Anneleen
  • Gene editing of a dominant pathogenic allele in human induced pluripotent stem cells (iPS) derived from myotonic dystrophy (DM1) patients - Dastidar Sumativa
  • Chemogenetic modulation of astrocytes in temporal lobe epilepsy and its comorbidities - De Bundel Dimitri
  • Improved targeted therapies in non-small cell lung cancer: an unbiased approach to increase treatment efficacy - De Grève Jacques
  • RNA therapy for beta cell regeneration and transplantation - De Leu Nico
  • The role of myeloid-derived suppressor cells in multiple myeloma drug resistance - De Veirman Kim
  • Characterisation of copy number variations posing a high safety risk upon transplantation of human pluripotent stem cell-derived cell populations - Geens Mieke
  • Investigating the genetic basis of lysosomal storage diseases by implementation of massive parallel sequencing - Gheldof Alexander
  • Development of polymer microparticles for beta cell therapy - Hellemans Karine
  • Beta cell generation by embryonic stem cell-derived implants in type 1 diabetes - Hilbrands Robert
  • A phase I study on the safety and immune-modulatory effect of intra-lesional administration of mRNA encoding dendritic cell activating proteins in patients with early breast cancer - Lamote Jan
  • Development and investigation of the feasibility and effects of a specific motion interactive game training the tibialis anterior muscle in children with cerebral palsy - Laumen Armand
  • Development of nanobody-based probes for pancreatic beta cell mass imaging - Massa Sam
  • Improving 3D-navigation for cervical dorsal root ganglion stimulation - Moens Maarten
  • Study of the pathogenic mechanisms of mutations in the SERPINC1 gene responsible for inherited antithrombin deficiency - Orlando Christelle
  • Establishing the role of autophagy, and its link with inflammation and cell death, in rodent models of temporal lobe epilepsy - Smolders Ilse
  • A 3D tissue culture model for screening of anti-fibrotic compounds - Van Grunsven Leo
  • Stratified phase IB clinical trial in patients with advanced melanoma and non-small cell lung cancer: investigating the combination of a natural dendritic cell vaccine plus an anti-PD-1 monoclonal antibody as first-line immunotherapy - Wilgenhof Sofie
  • High-resolution 3D imaging of microcalcifications using micro-CT - Willekens Inneke

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2014

  • Psychosocial support during pregnancy in vulnerable women. Randomised controlled trial measuring the effects on the routine antenatal care trajectory and perceived pscyhosocial stress - Beeckman Katrien
  • Beta cell protective and antidiabetic effects of aspalathin and a phenylpyruvic acid glucoside from rooibos – a preclinical study - Bouwens Luc
  • Exploring the continuum of functional decline across cognitively healthy ageing, Mild Cognitive Impairment and Alzheimer's disease, using The Brussels Integrated Activities of Daily Living questionnaire - Cornelis Elise
  • Analysis of the impact of tofacitinib on keratinocyte differentiation and immune function - Gutermuth Jan
  • Adaptive clinical trial program for combinatorial immunotherapy targeting cancer-testis antigens in patients with advanced colorectal cancer - Jansen Yanina
  • Towards the identification and characterization of novel gene defects in patients with a mitochondrial disease - Jonckheere An
  • Assesment of the added value of molecular karyotyping compared to standard karyotyping in couples with recurrent miscarriages - Keymolen Kathelijn
  • Development of a transposon-based stem cell-gene therapy for Duchenne muscular dystrophy - Loperfido Mariana
  • Use of whole genome next-generation sequencing (WG-NGS) in the typing and outbreak investigation of Shiga toxin-producing Escherichia coli (STEC) - Pierard Denis
  • Care and Place of Care at the End of Life: International Perspectives - Pivodic Lara
  • Effect of vitamin D deficiency on endometrial receptivity and oocyte quality in infertile women undergoing in vitro fertilization - Polyzos Nikolaos
  • Circulating nucleic acids as high-sensitivity biomarkers for occult beta cell destruction in type 1 diabetes - Roels Sarah
  • Genetic predisposition of ovarian hyperstimulation syndrome - dos Santos Ribeiro Samuel
  • Evaluation of the performance of an adapted endotracheal tube (i.e. double-cuffed with providing continuous positive pressure in the intercuff space) on inflow of oropharyngeal secretions in mechanically ventilated patients. An observational study - Spapen Herbert
  • Do mitochondrial DNA mutations play a role in the outcome of assisted reproduction technologies? - Spits Claudia
  • Fertility preservation in boys facing stem cell loss: translation to a clinical application - Tournaye Herman
  • The genetic complexity of Brugada syndrome: a multiple hit disease model? - Van Dooren Sonia
  • Investigation of trophectoderm regulators playing a role in human embryo implantation - Vandevelde Hilde

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2013

  • Assessment of arterial flow in distal foot arteries by current ultrasound technique: to determining its role in angiosome-guided revascularization in diabetic foot patients - Aerden Dimitri
  • Testing the epigenetic safety of IVM in children born at UZ Brussel and risk assessment of IVM using a mouse model - Anckaert Ellen
  • Clonal complexity in childhood acute lymphoblastic leukemia: biological significance and clinical impact - Bakkus Marleen
  • Long-term health outcome of young adults conceived by IntraCytoplasmic Sperm Injection (ICSI) - Belva Florence
  • Evaluation of the role of human mesenchymal stem cells in experimental islet transplantation - Heimberg Harry
  • Towards improved genetic diagnosis for hereditary breast and ovarian cancer - De Grève Jacques
  • Exploration of translational potential of human skin-derived precursor cells and their in vitro generated hepatic derivatives in experimental liver disease models - De Kock Joery
  • Arginase as a predictive biomarker and molecular target in chemo/radiotherapy of metastatic colorectal cancer - De Ridder Mark
  • Study on the T-cell immune response in frequently HIV-1 exposed but seronegative individuals - Demanet Christian
  • In vivo Characterization of Atherosclerotic Plaques with 18F-Labeled Nanobodies - Droogmans Steven
  • Non-invasive mapping of tumor hypoxia for Biologically Modulated Radiotherapy in patients with locally advanced head-and-neck cancer - Everaert Hendrik
  • METHODS/MODELS FOR IN VIVO STIMULATION OF BETA CELL REPLICATION - Hellemans Karine
  • Intra-operative NIR-fluorescence image-guidance during breast cancer surgery - Lahoutte Tony
  • Malformations of cortical development: identification of novel genes and their function - Jansen Anna
  • Validation of a novel combined hyperinsulinemic euglycemic / hyperglycaemic clamp technique to measure simultaneously insulin secretion and resistance in a single test and comparison with the mixed meal tolerance test - Keymeulen Bart
  • Therapeutic vaccination against HIV by direct administration of mRNA encoding HIV antigens and activation signals - Lacor Patrick
  • A phase I study on the feasibility and safety of mRNA immunotherapy in combination with RFA in patients with hepatocellular carcinoma - Reynaert Hendrik
  • Investigation of implantation regulators in the human embryo - Vandevelde Hilde
  • From an invasive to a non-invasive test for pregnancy outcome - Vercammen Martine
  • GNAS 1 autoantibodies as new marker for beta cell-directed autoimmunity in type 1 diabetes - Verhaegen Katrijn
  • Proinsulin/C-peptide ratio as a marker of functional beta cell mass in (pre) type 1 diabetes and in beta cell therapy - Weets Ilse

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2012

  • Prospective Randomized Control Trial on Cumulus Cell gene expression based: Pregnancy Prediction to improve the live birth rate in ICSI patients - Adriaenssens Tom
  • The neurobiological effects of high frequency repetitive transcranial magnetic stimulation (HF-rTMS) on alcohol craving in alcohol dependent patients - Baeken Chris
  • Pre-hospital Stroke Study at the Universitair ziekenhuis Brussel (PreSSUB) - Brouns Raf
  • Cerebral axonal and astrocytic energy metabolism and glutamate levels in multiple sclerosis - Cambron Melissa
  • Respiration-synchronized radiation of non-small cell lung cancer from the patient's point of view - Collen Christine
  • Development and evaluation of a computerised clinical decision support system for dosing guidance in patients with renal insufficiency - Cornu Pieter
  • Spermatogonial stem cell retrieval and cryopreservation in young boys with Klinefelter syndrome: an attempt to preserve their future fertility - De Schepper Jean
  • Therapeutic mRNA based immunotherapy of hr-HPV positive cervical intraepithelial neoplasia (CIN grade 2-3) - De Sutter Philippe
  • Beta Cell Therapy in Type 1 Diabetes - Keymeulen Bart
  • Development of a bead-based immunoassay for PPP1R1A as novel biomarker of beta cell destruction in vivo - Martens Geert
  • Neural influence in the resolution of type 2 diabetes mellitus after Roux-en-Y gastric bypass in patients with morbid obesity - Muylaert Caroline
  • Unraveling of genetic factors involved in male fertility - Stouffs Katrien
  • Fertility preservation in boys facing stem cell loss: translation to a clinical application - Tournaye Herman
  • Knee osteoarthritis exercise therapy (KNOET) - Vaes Peter
  • Development of innovative therapies to prevent or treat damages of the glomerular filtration barrier by mTOR antagonists and inhibitors of VEGF signaling - Van Beneden Katrien
  • Unraveling the molecular genetic pathways of Brugada syndrome by cardiomics research - Van Dooren Sonia
  • The immunology of implantation: the role of uterine dendritic cells - Vandevelde Hilde
  • Connexin hemichannels as drug targets in acute liver failure: a combined in vitro-in vivo study - Vinken Mathieu

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2011

  • Evidencing potential mechanisms involved in imprinting disorders after human Assisted Reproductive Technology - Anckaert Ellen
  • The effect of peri-operative anti-inflammatory treatment on postoperative muscle weakness and muscle fatigue in elderly elective surgery patients - Bautmans Ivan
  • Study of the intestinal microbiota in children with crohn’s disease (cd) and intervention with prebiotics or probiotics - De Greef Elisabeth
  • Preparation of alginate-embedded human islet cell grafts for transplantaion in diabetic patients - Gorus Frans
  • Insulin-like growth factor-based treatment for acute ischemic stroke - Kooijman Ron
  • Prospective comprehensive study of the new medical treatment options for patients with advanced melanoma - Neyns Bart
  • Impact of bilateral ganglion stellatum blockade on complex fractionated atrial electrograms during hybrid thoracoscopic ablation of atrial fibrillation - Sarkozy Andrea
  • Gene therapy for hemophylia "A" using "immune stealth" nanoparticles: preclinical validation in anticipation of phase I clinical trials in patients with severe hemophilia "A" - Vandendriessche Thierry
  • Prehospital stroke study at the Universitair Ziekenhuis Brussel (PreSSUB) - Brouns Raf
  • Biologically modulated radiotherapy for locally advanced pancreatic cancer on the VERO-SBRT system - Christian Nicolas
  • Validation of integrated backscatter echocardiography as a new tool for quantifying the degree of aortic valve calcification in patients - Cosyns Bernard
  • 13C gastric emptying breath tests in children: comparison of non-dispersive infrared spectrometry and isotope ratio-mass spectrometry tests - Hauser Bruno
  • Randomized phase III trial of preoperative radiotherapy with an integrated simultaneous boost compared to chemoradiotherapy for t3-4 rectal cancer: central pathology review and translational study - Hoorens Anne
  • Impact of the maze procedure in one atrial fibrillation on the sympathetic activity of the heart assessed by 123I-MIBG - La Meir Mark
  • The physical and psychological development of 5-year-old children born after preimplantation genetic diagnosis (PGD) compared to children born after intracytoplasmic sperm injection (ICSI) and natural conception - Nekkebroeck Julie
  • Characterisation of epidermal permeability barrier function in filaggrin deficient humans and mouse models - Roelandt Truus
  • DC VACCINES KNOCK YOUR SOX OFF: Preclinical and clinical studies to investigate the role of SOX2 as a potential target to induce cellular immune responses against myeloma cells - Schots Rik
  • Circulating tumor cells and circulating endothelial cells in operable NSCLC: a study on kinetics and molecular-genetic characteristics - Smets Dirk
  • Pregnancy outcome of ICSI cycles after closed incubation with time-lapse automated embryo evaluation or standard incubation with classical morphological embryo evaluation - Van de Velde Hilde

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